Beilstein J. Org. Chem.2022,18, 438–445, doi:10.3762/bjoc.18.46
syntheses of these drugs were obtained in high yields and enantiomeric excesses of up to 91% ee.
Keywords: asymmetric Henry reaction; enantioselective catalysis; linezolid; oxazolidine-2-onederivatives; rivaroxaban; Introduction
Oxazolidine-2-onederivatives represent an important branch of
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Graphical Abstract
Figure 1:
The structure of the oxazolidine-2-one-containing drugs linezolid (1) and rivaroxaban (2).